Tlk1 Gene Summary [Mouse]
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular protein transport; protein phosphorylation; and regulation of chromatin organization. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human TLK1 (tousled like kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tlk1 |
| Official Name | tousled-like kinase 1 [Source:MGI Symbol;Acc:MGI:2441683] |
| Ensembl ID | ENSMUSG00000041997 |
| Bio databases IDs | |
| Aliases | tousled-like kinase 1 |
| Synonyms | 4930545J15Rik, LOC103690017, PKU-beta, PKU-β, SNAK, Tlk1 predicted, tousled-like kinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Tlk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- pervasive developmental disorder
- chronic lymphocytic leukemia
- mucoepidermoid carcinoma
- salivary duct carcinoma
- salivary duct cancer
- acinar-cell carcinoma
role in cell
- organization
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tlk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromosome segregation
- chromatin organization
- protein phosphorylation
- intracellular protein transport
- response to DNA damage stimulus
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity