Mms22l Gene Summary [Mouse]
Predicted to enable single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; protein localization to chromatin; and replication fork processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of FACT complex and MCM complex. Predicted to be active in nuclear replication fork and site of double-strand break. Is expressed in cerebral cortex ventricular layer. Orthologous to human MMS22L (MMS22 like, DNA repair protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mms22l |
| Official Name | MMS22-like, DNA repair protein [Source:MGI Symbol;Acc:MGI:2684980] |
| Ensembl ID | ENSMUSG00000045751 |
| Bio databases IDs | |
| Aliases | MMS22-like, DNA repair protein |
| Synonyms | C6orf167, dJ39B17.2, F730047E07Rik, Gm134, MMS22-like, DNA repair protein, RGD1304693 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mms22l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-phase genomic integrity recombination mediator, C-terminal
- single-stranded DNA binding
- S-phase genomic integrity recombination mediator, N-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- lung cancer
role in cell
- cell death
- cell viability
- phosphorylation in
- quantity
- activation in
- formation
- formation in
- cell cycle progression
- synthesis in
- G2 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mms22l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to chromatin
- double-strand break repair via homologous recombination
- replication fork processing
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- FACT complex
- site of double-strand break
- nuclear replication fork
- cytosol
- MCM complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- single-stranded DNA binding