Polb Gene Summary [Mouse]
Predicted to enable several functions, including catalytic activity, acting on DNA; damaged DNA binding activity; and microtubule binding activity. Acts upstream of or within several processes, including base-excision repair, gap-filling; immune system development; and intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm and spindle microtubule. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in early conceptus; hemolymphoid system; muscle tissue; nervous system; and sensory organ. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human POLB (DNA polymerase beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polb |
| Official Name | polymerase (DNA directed), beta [Source:MGI Symbol;Acc:MGI:97740] |
| Ensembl ID | ENSMUSG00000031536 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), beta |
| Synonyms | A430088C08RIK, DNA pol beta, DNA polymerase beta, DNA polymerase β, DNA pol β, DNA β polymerase, Pol beta, polymerase (DNA directed), beta, polymerase (DNA directed), β, polymerase β, Pol β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Helix-hairpin-helix domain
- DNA polymerase beta thumb
- DNA-directed DNA polymerase
- DNA binding domain
- catalytic domain
- DNA polymerase X family
- metal ion binding
- DNA polymerases domain
- DNA-(apurinic or apyrimidinic site) lyase
- enzyme binding
- enzyme
- protein binding
- carbon-oxygen lyase
- DNA binding
- microtubule binding
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- damaged DNA binding
- lyase
- Fingers domain of DNA polymerase lambda
- active site
- DNA polymerase beta palm
- 5'-dRP lyase domain
Pathways
Biological processes and signaling networks where the Polb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- infection
- stage IV colorectal cancer
- hepatic fibrosis
- liver cancer
- childhood lymphoblastic lymphoma
- mature B-cell lymphoma
- advanced colon adenocarcinoma
- relapsed acute myeloid leukemia
- refractory acute myeloid leukemia
role in cell
- proliferation
- expression in
- accumulation in
- activation in
- cell death
- growth
- apoptosis
- cell cycle progression
- cell viability
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- microtubules
- bivalents
- nucleoplasm
- spindle fibers
- synaptonemal complexes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to hyperoxia
- immunoglobulin heavy chain V-D-J recombination
- DNA repair
- pyrimidine dimer repair
- base-excision repair
- DNA-dependent DNA replication
- spleen development
- lymph node development
- nucleotide-excision repair, DNA gap filling
- DNA damage response, signal transduction resulting in induction of apoptosis
- base-excision repair, gap-filling
- double-strand break repair via nonhomologous end joining
- response to DNA damage stimulus
- salivary gland morphogenesis
- response to ethanol
- inflammatory response
- in utero embryonic development
- homeostasis of number of cells
- DNA biosynthetic process
- response to gamma radiation
- neuron apoptotic process
- somatic hypermutation of immunoglobulin genes
Cellular Component
Where in the cell the gene product is active
- nucleus
- spindle microtubule
- cytoplasm
- macromolecular complex
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-directed DNA polymerase activity
- protein binding
- 5'-deoxyribose-5-phosphate lyase activity
- metal ion binding
- lyase activity
- DNA-(apurinic or apyrimidinic site) lyase activity
- damaged DNA binding
- microtubule binding
- enzyme binding