Nr2c1 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of retinoic acid receptor signaling pathway. Located in PML body. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nr2c1 |
| Official Name | nuclear receptor subfamily 2, group C, member 1 [Source:MGI Symbol;Acc:MGI:1352465] |
| Ensembl ID | ENSMUSG00000005897 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 2, group C, member 1 |
| Synonyms | 4831444H07RIK, 80.3, EENR, nuclear receptor subfamily 2 group C member 1, nuclear receptor subfamily 2, group C, member 1, Psg4, TR2, TR2-11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nr2c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- dimerization domain
- signaling receptor activity
- steroid hormone receptor
- DNA binding domain
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- nucleic acid binding
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- AF-1 domain
- ligand-binding domain
- double-stranded DNA binding
- protein homodimerization
- zinc finger domain
- Ligand-binding domain of nuclear hormone receptor
Pathways
Biological processes and signaling networks where the Nr2c1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatosplenomegaly
- sickle cell anemia
- coronary artery disease
role in cell
- quantity
- sumoylation in
- association in
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nr2c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of retinoic acid receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- anatomical structure development
- cell differentiation
- steroid hormone mediated signaling pathway
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- PML body
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- zinc ion binding
- protein homodimerization activity
- protein binding
- histone deacetylase binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- signaling receptor activity
- steroid hormone receptor activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity