Jazf1 Gene Summary [Mouse]
Predicted to enable transcription corepressor activity. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; limb bud; limb interdigital region mesenchyme; nervous system; and reproductive system. Orthologous to human JAZF1 (JAZF zinc finger 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Jazf1 |
| Official Name | JAZF zinc finger 1 [Source:MGI Symbol;Acc:MGI:2141450] |
| Ensembl ID | ENSMUSG00000063568 |
| Bio databases IDs | |
| Aliases | JAZF zinc finger 1 |
| Synonyms | AI591476, C820002C15, Jaz1, JAZF zinc finger 1, LOC682099, TIP27, ZNF802 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jazf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergy
- epithelial cancer
- cancer
- ovarian carcinoma
- epithelial ovarian cancer
- skin cancer
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- endometrial stromal sarcoma
- endometrial sarcoma cancer
role in cell
- expression in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jazf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- cytosol
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity