Cd248 Gene Summary [Mouse]
Enables extracellular matrix binding activity. Acts upstream of or within several processes, including fibroblast migration; lymph node development; and positive regulation of endothelial cell apoptotic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and skeleton. Orthologous to human CD248 (CD248 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd248 |
| Official Name | CD248 antigen, endosialin [Source:MGI Symbol;Acc:MGI:1917695] |
| Ensembl ID | ENSMUSG00000056481 |
| Bio databases IDs | |
| Aliases | CD248 antigen, endosialin |
| Synonyms | 2610111G01Rik, CD164L1, CD248 antigen, endosialin, CD248 molecule, ENDOSIALIN, LOC100911932, TEM1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd248 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- extracellular matrix binding
- Lectin C-type domain
- protein binding
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- scar tissue
- weight gain
- metastatic colorectal cancer
- idiopathic pulmonary fibrosis
- keloid
role in cell
- proliferation
- activation
- growth
- migration
- binding
- production by
- production
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd248 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- anatomical structure regression
- positive regulation of fibroblast proliferation
- lymph node development
- positive regulation of endothelial cell apoptotic process
- endothelial cell apoptotic process
- fibroblast migration
- cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- external side of plasma membrane
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- calcium ion binding
- carbohydrate binding