Shpk Gene Summary [Mouse]
Enables sedoheptulokinase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and pentose-phosphate shunt, non-oxidative branch. Located in cytoplasm. Is expressed in trigeminal ganglion. Orthologous to human SHPK (sedoheptulokinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Shpk |
| Official Name | sedoheptulokinase [Source:MGI Symbol;Acc:MGI:1921887] |
| Ensembl ID | ENSMUSG00000005951 |
| Bio databases IDs | |
| Aliases | sedoheptulokinase |
| Synonyms | 4930431K22Rik, CARKL, sedoheptulokinase, SHK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shpk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- sedoheptulokinase
- FGGY family of carbohydrate kinases, N-terminal domain
- protein binding
- D-xylulose kinase
- ASKHA_ATPase-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shpk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- pentose-phosphate shunt, non-oxidative branch
- carbohydrate metabolic process
- cellular response to lipopolysaccharide
- pentose-phosphate shunt
- regulation of macrophage activation
- cellular response to interleukin-4
- regulation of inflammatory response
- phosphorylation
- cellular response to interleukin-13
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- sedoheptulokinase activity
- ATP binding