Arfgap3 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Involved in presynaptic endocytosis. Is active in photoreceptor ribbon synapse and presynaptic active zone. Orthologous to human ARFGAP3 (ARF GTPase activating protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arfgap3 |
| Official Name | ADP-ribosylation factor GTPase activating protein 3 [Source:MGI Symbol;Acc:MGI:1913501] |
| Ensembl ID | ENSMUSG00000054277 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor GTPase activating protein 3 |
| Synonyms | 0610009H19Rik, 1810004P07Rik, 1810035F16Rik, 9130416J18Rik, ARFGAP1, ARF GTPase activating protein 3, FLJ10767, LOC100045474 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arfgap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative GTP-ase activating proteins for the small GTPase, ARF
- GTPase activator
- protein binding
- GTPase-activating protein (GAP) for the ADP ribosylation factors (ARFs)
- zDHHC ankyrin repeat binding domain
- Putative GTPase activating protein for Arf
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- perinuclear region
- Golgi Apparatus
- cytosol
- synapse
- ribbon synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arfgap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- COPI coating of Golgi vesicle
- intracellular protein transport
- protein secretion
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- Golgi apparatus
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- GTPase activator activity