Lrrc8e Gene Summary [Mouse]
Predicted to enable volume-sensitive anion channel activity. Involved in cyclic-GMP-AMP transmembrane import across plasma membrane. Predicted to be located in endoplasmic reticulum membrane and lysosomal membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8E (leucine rich repeat containing 8 VRAC subunit E). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrrc8e |
| Official Name | leucine rich repeat containing 8 family, member E [Source:MGI Symbol;Acc:MGI:1919517] |
| Ensembl ID | ENSMUSG00000046589 |
| Bio databases IDs | |
| Aliases | leucine rich repeat containing 8 family, member E |
| Synonyms | 1810049O03Rik, FLJ23420, leucine rich repeat containing 8 family, member E, leucine rich repeat containing 8 VRAC subunit E, RGD1311979 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrrc8e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- volume-sensitive anion channel
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- protein binding
- Pannexin-like TM region of LRRC8
- ion channel
Pathways
Biological processes and signaling networks where the Lrrc8e gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- angioedema
- diabetes mellitus
- osteosarcoma
- osteosarcomagenesis
- infection by HIV-1
regulated by
- CA9
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- endoplasmic reticulum membrane
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrrc8e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to osmotic stress
- aspartate transport
- cell volume homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoplasm
- ion channel complex
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- volume-sensitive anion channel activity