Psmf1 Gene Summary [Mouse]
Predicted to enable proteasome binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in negative regulation of proteasomal protein catabolic process and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. Predicted to be part of proteasome complex. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver and biliary system; and nervous system. Orthologous to human PSMF1 (proteasome inhibitor subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmf1 |
| Official Name | proteasome (prosome, macropain) inhibitor subunit 1 [Source:MGI Symbol;Acc:MGI:1346072] |
| Ensembl ID | ENSMUSG00000032869 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) inhibitor subunit 1 |
| Synonyms | LOC682071, PI31, proteasome inhibitor subunit 1, proteasome (prosome, macropain) inhibitor subunit 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- PI31 proteasome regulator
- protein homodimerization
- protein binding
- proline rich domain
- protein heterodimerization
- PI31 proteasome regulator N-terminal
Pathways
Biological processes and signaling networks where the Psmf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motor dysfunction
- acute myeloid leukemia
- kyphosis
- incoordination
regulates
- 20S proteasome
- casein
- succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
role in cell
- growth
- accumulation in
- accumulation
- swelling
- swelling in
- sprouting in
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- proteasome core complex
- membrane
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- proteasome binding
- protein homodimerization activity
- protein binding
- endopeptidase inhibitor activity
- protein heterodimerization activity