Crip2 Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Acts upstream of or within hemopoiesis and positive regulation of cell population proliferation. Located in cell cortex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut. Orthologous to human CRIP2 (cysteine rich protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crip2 |
| Official Name | cysteine rich protein 2 [Source:MGI Symbol;Acc:MGI:1915587] |
| Ensembl ID | ENSMUSG00000006356 |
| Bio databases IDs | |
| Aliases | cysteine rich protein 2 |
| Synonyms | 0610010I23Rik, CRIP, Crp, CRP2, CRP4, Cysteine-rich protein 2, ESP1, Hlp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crip2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- nasopharyngeal carcinoma
- nasopharyngeal cancer
- brain cancer
- medulloblastoma SHH subtype
- touch abnormality
regulates
- IL6
- NFkB (complex)
- CXCL8
- VEGF
role in cell
- expression in
- growth
- proliferation
- apoptosis
- migration
- surface area
- binding in
- tumorigenicity
- hematopoiesis
- angiogenic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell cortex
- Nucleus
- cytosol
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crip2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hemopoiesis
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- cell cortex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding