Rgs11 Gene Summary [Mouse]
Predicted to enable G-protein beta-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in dendrite terminus. Is active in cell tip and dendrite. Is expressed in several structures, including lower jaw molar; metanephros; nervous system; pancreas; and sensory organ epithelium. Orthologous to human RGS11 (regulator of G protein signaling 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Rgs11 |
| Official Name | regulator of G-protein signaling 11 [Source:MGI Symbol;Acc:MGI:1354739] |
| Ensembl ID | ENSMUSG00000024186 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 11 |
| Synonyms | regulator of G-protein signaling 11, RS11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulator of G protein signaling domain
- Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
- DEP
- GGL
- Regulator of G-protein signalling DHEX domain
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
- GGL domain
Pathways
Biological processes and signaling networks where the Rgs11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- dendrite tip
- cell tip
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- intracellular signal transduction
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- macromolecular complex
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein beta-subunit binding
- GTPase activity
- GTPase activator activity