Usp19 Gene Summary [Mouse]
Enables K48-linked deubiquitinase activity; cysteine-type deubiquitinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of skeletal muscle tissue development; protein K48-linked deubiquitination; and protein stabilization. Located in cytosol. Is expressed in ovary and primary sex cord. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp19 |
| Official Name | ubiquitin specific peptidase 19 [Source:MGI Symbol;Acc:MGI:1918722] |
| Ensembl ID | ENSMUSG00000006676 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 19 |
| Synonyms | 8430421I07RIK, ubiquitin specific peptidase 19, ZMYND9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- ubiquitin protein ligase binding
- Linker region of USP19 deubiquitinase
- MYND finger
- alpha-crystallin Hsps/p23-like
- peptidase
- heat shock protein binding
- ubiquitin-specific protease
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp19 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
role in cell
- phosphorylation in
- proliferation
- expression in
- degradation in
- binding in
- autophagy in
- apoptosis
- differentiation
- activation in
- atrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- regulation of protein stability
- negative regulation of skeletal muscle tissue development
- positive regulation of cell cycle process
- regulation of cellular response to hypoxia
- protein stabilization
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- metal ion binding
- Hsp90 protein binding