Syngr3 Gene Summary [Mouse]
Enables SH2 domain binding activity. Involved in positive regulation of transporter activity; regulated exocytosis; and regulation of synaptic vesicle priming. Located in synapse. Is active in neuromuscular junction and synaptic vesicle. Is expressed in several structures, including central nervous system; eye; and peripheral nervous system ganglion. Orthologous to human SYNGR3 (synaptogyrin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Syngr3 |
| Official Name | synaptogyrin 3 [Source:MGI Symbol;Acc:MGI:1341881] |
| Ensembl ID | ENSMUSG00000007021 |
| Bio databases IDs | |
| Aliases | synaptogyrin 3 |
| Synonyms | Synaptogyrin3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syngr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Membrane-associating domain
- intracellular loop
- SH2-domain binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- Parkinson disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- small cell lung cancer
- non-small cell lung cancer
- working memory deficit
- rotator cuff injury
regulates
- SLC6A3
- GH1
role in cell
- long-term potentiation in
- priming
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- synaptic vesicles
- neuromuscular junctions
- synaptosomes
- synapse
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syngr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulated secretory pathway
- regulation of neurotransmitter uptake
- positive regulation of transporter activity
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- membrane
- neuromuscular junction
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH2 domain binding