Rplp1 Gene Summary [Mouse]
Predicted to enable protein kinase activator activity and ribonucleoprotein complex binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within regulation of translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Orthologous to human RPLP1 (ribosomal protein lateral stalk subunit P1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rplp1 |
| Official Name | ribosomal protein, large, P1 [Source:MGI Symbol;Acc:MGI:1927099] |
| Ensembl ID | ENSMUSG00000007892 |
| Bio databases IDs | |
| Aliases | ribosomal protein, large, P1 |
| Synonyms | 2410042H16Rik, Arpp1, C430017H15Rik, FLJ21550, LP1, P1, Ribo Phosphoprotein P1, Ribosomal Phosphoprotein P1, Ribosomal protein large p1, ribosomal protein lateral stalk subunit P1, RPP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rplp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- ribonucleoprotein binding
- protein binding
- Ribosomal_P1_P2_L12p
Pathways
Biological processes and signaling networks where the Rplp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
disease
- myelodysplastic syndrome
- atrial fibrillation
- aortic valve calcification
- acute graft-vs-host disease
- hypertrophic scarring
phenotypes
- abnormal adipose tissue development
- abnormal intestine morphology
- abnormal liver morphology
- abnormal skin coloration
- abnormal tail morphology
- abnormal tail position or orientation
- decreased birth body size
- decreased erythroblast number
- impaired hematopoiesis
- kinked tail
- male infertility
- postnatal lethality incomplete penetrance
- short tail
- small thymus
role in cell
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- ribosome
- Plasma Membrane
- cytosol
- endoplasmic reticulum membrane
- synapse
- perikaryon
- dendrites
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rplp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- translational elongation
- translation
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytosolic ribosome
- cytoplasm
- cytosol
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of ribosome
- protein kinase activator activity
- ribonucleoprotein complex binding