Ackr2 Gene Summary [Mouse]
Enables C-C chemokine binding activity and C-C chemokine receptor activity. Acts upstream of or within signal transduction. Predicted to be located in several cellular components, including actin filament; cytosol; and nucleus. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; retina; and trophoblast giant cell. Orthologous to human ACKR2 (atypical chemokine receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ackr2 |
| Official Name | atypical chemokine receptor 2 [Source:MGI Symbol;Acc:MGI:1891697] |
| Ensembl ID | ENSMUSG00000044534 |
| Bio databases IDs | |
| Aliases | atypical chemokine receptor 2 |
| Synonyms | atypical chemokine receptor 2, CCBP2, CCR10, CCR9, CMBRK9, CMKBR9, D6, hD6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ackr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- C-C chemokine receptor
- Cholecystokinin A receptor, N-terminal
- chemokine receptor
- scavenger receptor
- C-C chemokine binding
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ackr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Huntington disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- weight loss
- skin neoplasia
- dextran sodium sulfate-induced colitis
- abortion
- psoriasis
- dermatitis
role in cell
- chemotaxis
- migration
- expression in
- binding
- phosphorylation in
- number
- accumulation
- reprogramming
- localization
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- cellular membrane
- vesicles
- actin filaments
- granules
- cytosol
- nucleoplasm
- nuclear envelope
- recycling endosomes
- early endosomes
- perinuclear vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ackr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- vesicle-mediated transport
- immune response
- chemokine-mediated signaling pathway
- calcium-mediated signaling
- intracellular signal transduction
- elevation of cytosolic calcium ion concentration
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- early endosome
- intracellular membrane-bounded organelle
- external side of plasma membrane
- cytosol
- recycling endosome
- actin filament
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- C-C chemokine binding
- protein binding
- C-C chemokine receptor activity
- scavenger receptor activity
- chemokine receptor activity