Ube2g2 Gene Summary [Mouse]
Enables identical protein binding activity and ubiquitin conjugating enzyme activity. Acts upstream of or within ERAD pathway. Located in cytosol and endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human UBE2G2 (ubiquitin conjugating enzyme E2 G2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2g2 |
| Official Name | ubiquitin-conjugating enzyme E2G 2 [Source:MGI Symbol;Acc:MGI:1343188] |
| Ensembl ID | ENSMUSG00000009293 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2G 2 |
| Synonyms | 1110003O05Rik, D10Xrf369, E2G 2, UBC7, Ubc7p, ubiquitin-conjugating enzyme E2G 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2g2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin conjugating enzyme
- ubiquitin-protein transferase activity
- UBCc_UEV
- enzyme
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Ube2g2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- Down syndrome
- psoriatic arthritis
role in cell
- degradation in
- cell viability
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2g2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein K48-linked ubiquitination
- cellular response to interferon-beta
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ATP binding
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding