Mdga2 Gene Summary [Mouse]
Involved in regulation of presynapse assembly and regulation of synaptic membrane adhesion. Acts upstream of or within several processes, including motor behavior; negative regulation of neuron apoptotic process; and neuron migration. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in cortical plate. Used to study amyotrophic lateral sclerosis type 18. Orthologous to human MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mdga2 |
| Official Name | MAM domain containing glycosylphosphatidylinositol anchor 2 [Source:MGI Symbol;Acc:MGI:2444706] |
| Ensembl ID | ENSMUSG00000034912 |
| Bio databases IDs | |
| Aliases | MAM domain containing glycosylphosphatidylinositol anchor 2 |
| Synonyms | 6720489L24RIK, 9330209L04RIK, Adp, c14 5286, MAMDC1, MAM domain containing glycosylphosphatidylinositol anchor 2, Tg(Prnp-PFN1*G118V)838Kiaei |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mdga2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- MAM domain, meprin/A5/mu
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- clear cell sarcoma of the kidney
- renal cancer
- soft tissue sarcoma cancer
- neuroticism
- food allergy
- major depression
- ocular sarcoidosis
- gastric cancer
regulated by
- topotecan
- methylphenidate
- levodopa
role in cell
- expression in
- migration
- apoptosis
- differentiation
- growth
- proliferation
- stabilization in
- colony formation
- adhesion
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Extracellular Space
- cellular membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mdga2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spinal cord motor neuron differentiation
- nervous system development
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane