Acaa1b Gene Summary [Mouse]
Enables acetyl-CoA C-acyltransferase activity. Involved in fatty acid derivative biosynthetic process and fatty acid metabolic process. Located in mitochondrion. Is active in peroxisomal matrix. Is expressed in several structures, including alimentary system; ganglia; genitourinary system; metencephalon basal plate; and submandibular gland primordium. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acaa1b |
| Official Name | acetyl-Coenzyme A acyltransferase 1B [Source:MGI Symbol;Acc:MGI:3605455] |
| Ensembl ID | ENSMUSG00000010651 |
| Bio databases IDs | |
| Aliases | acetyl-Coenzyme A acyltransferase 1B |
| Synonyms | ACAA, Acaa1b, acetyl-CoA acyltransferase 1, acetyl-Coenzyme A acyltransferase 1B, Lnc-Myd88, MGC29978, peroxisomal 3-oxoacyl-Coenzyme A thiolase, PTHIO, THIO, THIOL, THIOLASE, Thiolase b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acaa1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thiolase, N-terminal domain
- cond_enzymes
- acetyl-CoA C-acyltransferase
- peroxisome targeting signal 2
- acetyl-CoA acetyltransferases
- acetate CoA-transferase
- Thiolase, C-terminal domain
- enzyme
- acetyl-CoA C-myristoyltransferase
- protein binding
- Beta-ketoacyl synthase, C-terminal domain
- palmitoyl-CoA oxidase
Pathways
Biological processes and signaling networks where the Acaa1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- unstable angina
- disorder of coronary artery
- non-insulin-dependent diabetes mellitus
- COVID-19
- liver cancer
- epithelial cancer
- diabetes mellitus
- cardiotoxicity
- hepatitis B virus-related hepatocellular carcinoma
- coronary disease
role in cell
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- secretory granule lumen
- Extracellular Space
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acaa1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid beta-oxidation
- fatty acid beta-oxidation using acyl-CoA oxidase
- alpha-linolenic acid metabolic process
- very long-chain fatty acid metabolic process
- bile acid metabolic process
- phenylacetate catabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- specific granule lumen
- membrane
- cytosol
- peroxisomal matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA C-acetyltransferase activity
- protein binding
- acetyl-CoA C-acyltransferase activity
- acetate CoA-transferase activity
- palmitoyl-CoA oxidase activity
- acetyl-CoA C-myristoyltransferase activity