Hat1 Gene Summary [Mouse]
Predicted to enable histone H4K12 acetyltransferase activity. Predicted to be involved in subtelomeric heterochromatin formation. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain; liver; optic nerve; testis; and thymus primordium. Orthologous to human HAT1 (histone acetyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hat1 |
| Official Name | histone aminotransferase 1 [Source:MGI Symbol;Acc:MGI:96013] |
| Ensembl ID | ENSMUSG00000027018 |
| Bio databases IDs | |
| Aliases | histone aminotransferase 1 |
| Synonyms | 2410071B14Rik, histone acetyltransferase 1, histone aminotransferase 1, KAT1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase
- Histone acetyl transferase HAT1 N-terminus
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Hat1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- septic shock
- schizophrenia
- myopia
- non-insulin-dependent diabetes mellitus
- respiratory failure
- Waldenström macroglobulinemia
- premature aging
- neoplastic histiocytosis
role in cell
- expression in
- apoptosis
- binding in
- proliferation
- size
- colony formation by
- assembly
- organization
- structure
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- telomeric heterochromatin assembly
- chromosome organization
- internal protein amino acid acetylation
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- mitochondrion
- nuclear matrix
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- protein binding
- histone binding
- H4 histone acetyltransferase activity
- histone acetyltransferase activity (H4-K12 specific)