Zfp296 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in spermatogenesis. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including bone marrow; central nervous system; early conceptus; gonad; and ureter. Orthologous to human ZNF296 (zinc finger protein 296). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp296 |
| Official Name | zinc finger protein 296 [Source:MGI Symbol;Acc:MGI:1926956] |
| Ensembl ID | ENSMUSG00000011267 |
| Bio databases IDs | |
| Aliases | zinc finger protein 296 |
| Synonyms | 2210018A16Rik, ZFP296, zinc finger protein 296, ZNF342 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp296 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- double-stranded DNA binding
- Zinc-finger double domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- facioscapulohumeral muscular dystrophy type 2
- oligozoospermia
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- number
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp296 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendrite development
- negative regulation of transcription from RNA polymerase II promoter
- spermatogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding