Sapcd2 Gene Summary [Mouse]
Involved in establishment of mitotic spindle orientation; regulation of establishment of planar polarity; and symmetric cell division. Located in apical cortex. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and neural ectoderm. Orthologous to human SAPCD2 (suppressor APC domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sapcd2 |
| Official Name | suppressor APC domain containing 2 [Source:MGI Symbol;Acc:MGI:1919330] |
| Ensembl ID | ENSMUSG00000026955 |
| Bio databases IDs | |
| Aliases | suppressor APC domain containing 2 |
| Synonyms | 2010317E24Rik, 6030458L21Rik, ang, C9orf140, LOC687229, p42.3, suppressor APC domain containing 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sapcd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Adenomatous polyposis coli tumour suppressor protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- organismal death
role in cell
- proliferation
- migration
- growth
- quantity
- downregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- intercellular junctions
- cytosol
- nucleoplasm
- nucleoli
- apical cortex
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sapcd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- establishment of mitotic spindle orientation
- positive regulation of cell proliferation
- regulation of establishment of planar polarity
Cellular Component
Where in the cell the gene product is active
- tight junction
- apical junction complex
- cytosol
- apical cortex
- nucleolus
- apical plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding