Irf9 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be part of ISGF3 complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in immunodeficiency 65. Orthologous to human IRF9 (interferon regulatory factor 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irf9 |
| Official Name | interferon regulatory factor 9 [Source:MGI Symbol;Acc:MGI:107587] |
| Ensembl ID | ENSMUSG00000002325 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 9 |
| Synonyms | interferon regulatory factor 9, INTERFERON-STIMULATING TRANSCRIPTION FACTOR 3 gamma, INTERFERON-STIMULATING TRANSCRIPTION FACTOR 3 γ, ISGF3, ISGF3G, isgf3 γ, p48 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irf9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- STAT binding domain
- transcription regulator
- ISGF3a binding domain
- DNA binding domain
- nucleic acid binding
- IRF
- Irf binding domain
- linker domain
- Interferon-regulatory factor 3
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- transcription factor activity
Pathways
Biological processes and signaling networks where the Irf9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurological deficiency
- psoriasis
- colorectal neoplasia
- gastrointestinal neoplasia
- androgenic alopecia
- diabetic nephropathy
- limited systemic sclerosis
- perivascular fibrosis
- idiopathic inflammatory myopathy
- cardiac hypertrophy
role in cell
- expression in
- production in
- cell death
- differentiation
- activation in
- survival
- binding in
- cell cycle progression
- antiviral response
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irf9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- transcription from RNA polymerase II promoter
- cell surface receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- immune system process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ISGF3 complex
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity