Plagl2 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including chylomicron assembly; positive regulation of intrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human PLAGL2 (PLAG1 like zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plagl2 |
| Official Name | pleiomorphic adenoma gene-like 2 [Source:MGI Symbol;Acc:MGI:1933165] |
| Ensembl ID | ENSMUSG00000051413 |
| Bio databases IDs | |
| Aliases | pleiomorphic adenoma gene-like 2 |
| Synonyms | mKIAA0198, PLAG1 like zinc finger 2, pleiomorphic adenoma gene-like 2, PLEOMORPHIC ADENOMA GENE-LIKE 2, ZNF900 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plagl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- Zinc-finger double domain
- protein binding
- zinc finger domain
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- metabolic syndrome X
- weight gain
- bladder cancer
- acute myeloid leukemia
- metastasis
- acute myeloid leukemia with inv(16)
role in cell
- expression in
- proliferation
- activation in
- expansion
- apoptosis
- number
- growth
- invasion by
- G1/S phase transition
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plagl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- post-embryonic development
- lipid metabolic process
- chylomicron assembly
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of intrinsic apoptotic signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity