Nrcam Gene Summary [Mouse]
Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in cell-cell adhesion; nervous system development; and regulation of postsynapse organization. Acts upstream of or within several processes, including neuron development; neuronal action potential propagation; and regulation of neuron projection development. Located in axon; plasma membrane; and synapse. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NRCAM (neuronal cell adhesion molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Nrcam |
| Official Name | neuronal cell adhesion molecule [Source:MGI Symbol;Acc:MGI:104750] |
| Ensembl ID | ENSMUSG00000020598 |
| Bio databases IDs | |
| Aliases | neuronal cell adhesion molecule |
| Synonyms | Bravo, C030017F07Rik, C130076O07RIK, mKIAA0343, NEDNMS, neuronal cell adhesion molecule, NGCAM, NRCAM isoform 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrcam often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobulin domain
- cell adhesion molecule binding
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- fibronectin III-like domain
- ankyrin binding domain
- ankyrin binding
- FN3
- Immunoglobulin like
- PDZ binding motif
- Bravo-like intracellular region
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with neuromuscular and skeletal abnormalities
- pervasive developmental disorder
- experimental autoimmune encephalomyelitis
- multiple sclerosis
- ataxia
- hemangioma
- angiomatosis
- demyelination
- small cell lung cancer
- orofacial cleft
role in cell
- assembly
- expression in
- quantity
- binding in
- growth
- formation
- accumulation in
- loss in
- invasion
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- axon component
- cell surface
- cellular membrane
- vesicles
- cell-cell contacts
- postsynaptic membrane
- synaptic membrane
- nodes of Ranvier
- dendritic spine head
- axonal membrane
- growth cone
- axon initial segments
- synapse
- transport vesicles
- gap junctions
- retinal ganglion cell axon
- membrane rafts
- cellular protrusions
- membrane processes
- microvilli
- filopodia
- filopodial tip
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrcam gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinal ganglion cell axon guidance
- protein localization
- positive regulation of neuron differentiation
- axon guidance
- brain development
- axonal fasciculation
- clustering of voltage-gated sodium channels
- neuron migration
- synapse assembly
- regulation of axon extension
- central nervous system development
- angiogenesis
- axonogenesis
- regulation of neuron projection development
- heterotypic cell-cell adhesion
- neuronal action potential propagation
Cellular Component
Where in the cell the gene product is active
- initial segment
- external side of plasma membrane
- extracellular region
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ankyrin binding
- protein binding involved in heterotypic cell-cell adhesion