Homer2 Gene Summary [Mouse]
Enables actin binding activity and synaptic receptor adaptor activity. Involved in sensory perception of sound. Acts upstream of or within behavioral response to cocaine; calcium-mediated signaling; and regulation of G protein-coupled receptor signaling pathway. Located in apical part of cell; cytoplasm; and stereocilium tip. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; cranial nerve; jaw; sensory organ; and tongue. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to human HOMER2 (homer scaffold protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Homer2 |
| Official Name | homer scaffolding protein 2 [Source:MGI Symbol;Acc:MGI:1347354] |
| Ensembl ID | ENSMUSG00000025813 |
| Bio databases IDs | |
| Aliases | homer scaffolding protein 2 |
| Synonyms | 9330120H11RIK, ACPD, CPD, Cupidin, DFNA68, homer scaffolding protein 2, homer scaffold protein 2, VESL-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Homer2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- binding protein
- actin binding
- G-protein-coupled receptor binding
- protein domain specific binding
- GKAP/Homer scaffold
- EVH1 domain
- protein binding
- receptor binding
- Pleckstrin homology-like domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Homer2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- autosomal dominant deafness type 68
- touch abnormality
- coronary artery disease
- familial nonsyndromic hearing impairment
- bipolar disorder
role in cell
- production in
- activation in
- calcium oscillation
- detection in
- coupling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- nuclear fraction
- soluble fraction
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- organelle
- Cytoplasm
- apical compartment
- postsynaptic region
- cell-cell contacts
- cytosol
- stereocilia
- perikaryon
- dendrites
- postsynaptic density
- detergent-soluble fraction
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Homer2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- negative regulation of interleukin-2 production
- behavioral response to cocaine
- negative regulation of calcineurin-NFAT signaling cascade
- regulation of G-protein coupled receptor protein signaling pathway
- G-protein coupled glutamate receptor signaling pathway
- regulation of store-operated calcium entry
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- intracellular organelle
- apical part of cell
- cytoplasm
- cytosol
- stereocilium bundle tip
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein coupled glutamate receptor binding
- actin binding
- GKAP/Homer scaffold activity