Abcc8 Gene Summary [Mouse]
Enables ADP binding activity and ATP binding activity. Involved in negative regulation of insulin secretion and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within several processes, including action potential; glutamate secretion, neurotransmission; and neuromuscular process. Part of protein-containing complex. Is active in plasma membrane. Is expressed in cerebral cortex; foregut-midgut junction; heart ventricle; and retina inner nuclear layer. Used to study hyperinsulinemic hypoglycemia and transient neonatal diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple) and hypertension. Orthologous to human ABCC8 (ATP binding cassette subfamily C member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcc8 |
| Official Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 [Source:MGI Symbol;Acc:MGI:1352629] |
| Ensembl ID | ENSMUSG00000040136 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
| Synonyms | ABC36, ABCC8 (MODY12), ATP binding cassette subfamily C member 8, ATP-binding cassette, sub-family C member 8, D930031B21, D930031B21Rik, HHF1, HI, HRINS, hyperinsulinaemia, MRP8, PHHI, PNDM3, SULFONYLUREA receptor, sulfonylurea receptor 1, sulphONYLUREA receptor, sulphonylurea receptor 1, SUR, SUR1, SUR1delta2, TNDM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcc8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ADP binding
- ATP binding
- type I secretion system ABC transporter, PrtD family
- heme ABC exporter, ATP-binding protein CcmA
- nucleotide-binding domain
- zinc ion binding
- thiol reductant ABC exporter, CydC subunit
- ion channel binding
- multi drug resistance-associated protein (MRP)
- nickel import ATP-binding protein NikE
- nucleotide binding fold domain
- thiamine ABC transporter, ATP-binding protein
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- potassium channel
- lipid A export permease/ATP-binding protein MsbA
- cation-transporting ATPase
- ATP-activated inward rectifier potassium channel
- protein binding
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- cystic fibrosis transmembrane conductor regulator (CFTR)
- transmembrane domain
- ABC transporter
- transporter
Pathways
Biological processes and signaling networks where the Abcc8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hyperglycemia
- liver disease
- bleeding
- hypertension
- seizures
- familial hyperinsulinemic hypoglycemia 1
- diabetes mellitus
- cardiovascular death
- late-onset noninsulin-dependent diabetes mellitus
role in cell
- proliferation
- action potential
- depolarization
- disassembly
- migration by
- transactivation in
- response
- retention in
- homeostasis in
- secretion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- Cytoplasm
- cellular membrane
- Nucleus
- Mitochondria
- cytosol
- presynaptic membrane
- nuclear envelope
- synaptosomes
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abcc8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of glial cell proliferation
- negative regulation of angiogenesis
- transmembrane transport
- potassium ion transmembrane transport
- response to zinc ion
- neuromuscular process
- female pregnancy
- visual learning
- response to pH
- positive regulation of potassium ion transport
- response to xenobiotic stimulus
- negative regulation of insulin secretion
- positive regulation of uterine smooth muscle relaxation
- memory
- potassium ion transport
- response to insulin stimulus
- negative regulation of low-density lipoprotein particle clearance
- cellular glucose homeostasis
- positive regulation of tumor necrosis factor production
- response to lipopolysaccharide
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
Cellular Component
Where in the cell the gene product is active
- ATP-sensitive potassium channel complex
- sarcolemma
- membrane
- synaptic vesicle membrane
- plasma membrane
- potassium ion-transporting ATPase complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- sulfonylurea receptor activity
- ATPase activity, coupled to transmembrane movement of substances
- cation-transporting ATPase activity
- ATP-activated inward rectifier potassium channel activity
- ADP binding
- potassium channel activity
- ion channel binding