Scarf2 Gene Summary [Mouse]
Enables scavenger receptor activity. Acts upstream of or within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Predicted to be located in membrane. Is expressed in brain; metanephros; skin; thoracic segment skeleton; and trachea. Human ortholog(s) of this gene implicated in Van den Ende-Gupta syndrome. Orthologous to human SCARF2 (scavenger receptor class F member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scarf2 |
| Official Name | scavenger receptor class F, member 2 [Source:MGI Symbol;Acc:MGI:1858430] |
| Ensembl ID | ENSMUSG00000012017 |
| Bio databases IDs | |
| Aliases | scavenger receptor class F, member 2 |
| Synonyms | AI194363, NSR1, Scatf1, scavenger receptor class F member 2, scavenger receptor class F, member 2, SREC2, SREC-II, SRECRP-1, VDEGS, W53987, W65560 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scarf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- scavenger receptor
- protein binding
- transmembrane receptor
- EGF_CA
- Laminin EGF domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scarf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- heterophilic cell-cell adhesion
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- scavenger receptor activity