Ptprs Gene Summary [Mouse]
Enables chondroitin sulfate binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and regulation of postsynaptic density assembly. Acts upstream of or within central nervous system development and establishment of endothelial intestinal barrier. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and presynaptic membrane. Is expressed in several structures, including adipose tissue; genitourinary system; gut; nervous system; and sensory organ. Orthologous to human PTPRS (protein tyrosine phosphatase receptor type S). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptprs |
| Official Name | protein tyrosine phosphatase, receptor type, S [Source:MGI Symbol;Acc:MGI:97815] |
| Ensembl ID | ENSMUSG00000013236 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, receptor type, S |
| Synonyms | Lar-ptp2, protein tyrosine phosphatase receptor type S, protein tyrosine phosphatase, receptor type, S, PTP, PTP-NU3, Ptprd, PTPSIGMA, Ptpsigma., Ptpt9, PTP-σ, Rptpd, R-PTP-S, R-PTP-sigma, R-PTP-σ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptprs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein-tyrosine-phoshatase
- catalytic domain
- ectodomain
- immunoglobulin domain
- Protein tyrosine phosphatase, catalytic domain
- Purple acid Phosphatase, N-terminal domain
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- glycosaminoglycan binding
- PTPase domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- binding protein
- protein phosphatase
- FN3
- Immunoglobulin like
- transmembrane domain
- phosphatase
- intracellular domain
- heparin binding
Pathways
Biological processes and signaling networks where the Ptprs gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- sarcomatoid nasopharyngeal carcinoma
- sarcomatoid cancer
- nasopharyngeal cancer
- non-insulin-dependent diabetes mellitus
- atresia
- hypoplasia
- insomnia
- mixed sarcomatoid-epithelial nasopharyngeal carcinoma
- mixed neoplasia
role in cell
- phosphorylation in
- adhesion
- activation in
- colony formation
- organization
- assembly
- number
- regeneration
- development
- synaptic transmission in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- intercellular junctions
- desmosomes
- cell-cell contacts
- cytosol
- presynaptic membrane
- synaptic membrane
- synaptic vesicles
- growth cone
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptprs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cerebellum development
- negative regulation of dendritic spine development
- protein dephosphorylation
- negative regulation of toll-like receptor 9 signaling pathway
- hippocampus development
- cerebral cortex development
- corpus callosum development
- spinal cord development
- negative regulation of collateral sprouting
- negative regulation of axon regeneration
- negative regulation of neuron projection development
- negative regulation of axon extension
- regulation of synaptic transmission
- peptidyl-tyrosine dephosphorylation
- negative regulation of interferon-alpha production
- negative regulation of interferon-beta production
Cellular Component
Where in the cell the gene product is active
- growth cone
- presynaptic membrane
- extracellular vesicular exosome
- cytosol
- synaptic vesicle membrane
- perikaryon
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- chondroitin sulfate binding
- phosphoprotein phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- heparan sulfate proteoglycan binding
- heparin binding