Pea15a Gene Summary [Mouse]
This gene encodes an adaptor protein that functions as a negative regulator of apoptosis induced by tumor necrosis factor-alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas, through its interaction with fas-associated protein with death domain and caspase-8. It also regulates proliferation signaling by relocating the extracellular signal-regulated protein kinases 1 and 2 to the cytosol. The protein encoded by this gene contains an N-terminal death effector domain and a long, flexible C-terminal tail. In humans, the encoded protein is an endogenous substrate for protein kinase C. This protein is overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | Pea15a |
| Official Name | phosphoprotein enriched in astrocytes 15A [Source:MGI Symbol;Acc:MGI:104799] |
| Ensembl ID | ENSMUSG00000013698 |
| Bio databases IDs | |
| Aliases | phosphoprotein enriched in astrocytes 15A |
| Synonyms | HMAT1, HUMMAT1H, MAT1, MAT1H, Pea15a, PED, PED-PEA15, PED/PEA15, Pkcs15, proliferation and apoptosis adaptor protein 15, proliferation and apoptosis adaptor protein 15A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pea15a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death effector domain
- protein kinase C binding
- protein binding
- Death Domain Superfamily of protein-protein interaction domains
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- papillomatosis
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- cancer
- non-small cell lung cancer
- survival
- non-insulin-dependent diabetes mellitus
- invasive breast cancer
- systemic lupus erythematosus
role in cell
- expression in
- cell death
- accumulation in
- survival
- apoptosis
- invasion by
- activation in
- proliferation
- phosphorylation in
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- filamentous network
- Mitochondria
- microtubules
- cytosol
- nucleoplasm
- perinuclear vesicles
- thin filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pea15a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- apoptotic process
- negative regulation of glucose import
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- cytosol
- microtubule associated complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding