Klhl3 Gene Summary [Mouse]
Predicted to enable cullin family protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including potassium ion homeostasis; protein modification process; and renal sodium ion absorption. Predicted to be located in cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol. Is expressed in endocrine gland; genitourinary system; heart; lung; and nervous system. Used to study pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Klhl3 |
| Official Name | kelch-like 3 [Source:MGI Symbol;Acc:MGI:2445185] |
| Ensembl ID | ENSMUSG00000014164 |
| Bio databases IDs | |
| Aliases | kelch-like 3 |
| Synonyms | 7530408C15RIK, AI430941, EG627648, kelch-like 3, kelch-like family member 3, LOC102549506, PHA2D, RGD1565218 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding activity, bridging
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- structural molecule
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- malaria
- autosomal recessive pseudohypoaldosteronism type IID
- pseudohypoaldosteronism type IIA
- pseudohypoaldosteronism type IID
- hereditary disorder
- heart failure
- autosomal dominant pseudohypoaldosteronism type IID
- atrial fibrillation
- chronic hyperchloremic metabolic acidosis
- primary prostate cancer
role in cell
- degradation in
- expression in
- proliferation
- binding in
- cell viability
- ubiquitination in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal sodium ion absorption
- proteasomal ubiquitin-dependent protein catabolic process
- protein K48-linked ubiquitination
- potassium ion homeostasis
- distal tubule morphogenesis
- gene expression
- ion homeostasis
- macroautophagy
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- cytosol
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- structural molecule activity