Dnajc7 Gene Summary [Mouse]
Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Dnajc7 |
| Official Name | DnaJ heat shock protein family (Hsp40) member C7 [Source:MGI Symbol;Acc:MGI:1928373] |
| Ensembl ID | ENSMUSG00000014195 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member C7 |
| Synonyms | 2010003F24Rik, 2010004G07Rik, CCRP, DJ11, DJC7, DnaJ heat shock protein family (Hsp40) member C7, mDj11, mTpr2, TPR2, TTC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnajc7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- ATPase stimulator
- DnaJ
- TPR repeat
- DnaJ molecular chaperone homology domain
- Tetratricopeptide repeats
- heat shock protein binding
- protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Dnajc7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- major depression
- hepatic steatosis
- amyotrophic lateral sclerosis
- infection by Influenza A virus subtype H1N1
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnajc7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cellular response to heat
- chaperone mediated protein folding requiring cofactor
- protein folding
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- heat shock protein binding
- protein binding
- ATPase activator activity