Surf4 Gene Summary [Mouse]
Enables COPII receptor activity. Involved in COPII-coated vesicle cargo loading; lipid export from cell; and lipoprotein transport. Predicted to be located in Golgi apparatus; cytosol; and nuclear membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in embryo and pancreas tip epithelium. Orthologous to human SURF4 (surfeit 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Surf4 |
| Official Name | surfeit gene 4 [Source:MGI Symbol;Acc:MGI:98445] |
| Ensembl ID | ENSMUSG00000014867 |
| Bio databases IDs | |
| Aliases | surfeit gene 4 |
| Synonyms | ERV29, LOC102553670, surfeit 4, surfeit gene 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Surf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cargo receptor activity
- protein binding
- DoxX
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atherosclerosis
- ovarian carcinoma
- epithelial ovarian cancer
role in cell
- growth
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- lysosome membrane
- nuclear envelope
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Surf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- protein exit from endoplasmic reticulum
- lipid homeostasis
- Golgi organization
- positive regulation of organelle organization
- cargo loading into COPII-coated vesicle
- early endosome to Golgi transport
- regulation of lipid transport
- lipoprotein transport
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- plasma membrane
- endoplasmic reticulum membrane
- nuclear membrane
- cytosol
- ER to Golgi transport vesicle
- endoplasmic reticulum exit site
- transport vesicle
- azurophil granule membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cargo receptor activity
- COPII adaptor activity