Kdelr1 Gene Summary [Mouse]
Predicted to enable KDEL sequence binding activity. Acts upstream of or within T cell apoptotic process and T cell differentiation. Located in cis-Golgi network and endoplasmic reticulum. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human KDELR1 (KDEL endoplasmic reticulum protein retention receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kdelr1 |
| Official Name | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 [Source:MGI Symbol;Acc:MGI:1915387] |
| Ensembl ID | ENSMUSG00000002778 |
| Bio databases IDs | |
| Aliases | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 |
| Synonyms | 8030486F04Rik, ERD2, ERD2.1, HDEL, KDEL endoplasmic reticulum protein retention receptor 1, KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1, KDELR, KDEL receptor, LOC102724003, PM23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kdelr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KDEL sequence binding
- cytoplasmic domain
- transmembrane domain
- protein binding
- cytosolic tail domain
- ER lumen protein retaining receptor
- transporter
Pathways
Biological processes and signaling networks where the Kdelr1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
role in cell
- cell death
- apoptosis
- differentiation
- endoplasmic reticulum stress response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-intermediate compartment membrane fractions
- cell surface
- Golgi region
- perinuclear region
- membrane surface
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- Golgi membrane
- Golgi buds
- Golgi stacks
- Golgi cisternae rim
- cis Golgi networks
- peri-Golgi vesicles
- transport vesicles
- Golgi cisternae
- clathrin-coated vesicles
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kdelr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- ER to Golgi vesicle-mediated transport
- retrograde vesicle-mediated transport, Golgi to ER
- protein transport
- T cell apoptotic process
- protein retention in ER lumen
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cis-Golgi network
- Golgi membrane
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
- transport vesicle
- COPI coated vesicle membrane
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- KDEL sequence binding
- ER retention sequence binding