Rgl2 Gene Summary [Mouse]
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of Ral protein signal transduction. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; integumental system; and nervous system. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rgl2 |
| Official Name | ral guanine nucleotide dissociation stimulator-like 2 [Source:MGI Symbol;Acc:MGI:107483] |
| Ensembl ID | ENSMUSG00000041354 |
| Bio databases IDs | |
| Aliases | ral guanine nucleotide dissociation stimulator-like 2 |
| Synonyms | HKE1.5, KE1.5, RAB2L, Ralgdsl2, ral guanine nucleotide dissociation stimulator-like 2, Rgt2, Rlf |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CAAX box
- Ras-binding domain
- guanyl-nucleotide exchange factor
- Ubl1_cv_Nsp3_N-like
- Ras/Rap binding domain
- protein binding
- RasGEF
- REM
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal carcinoma
- colorectal carcinomagenesis
- tumorigenesis
- polyarticular juvenile rheumatoid arthritis
role in cell
- growth
- proliferation
- binding in
- differentiation
- transformation
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of Ral protein signal transduction
- Ras protein signal transduction
- negative regulation of cardiac muscle cell apoptotic process
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- guanyl-nucleotide exchange factor activity