Lgr6 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity and protein-hormone receptor activity. Acts upstream of or within bone regeneration and cell population proliferation. Predicted to be located in vesicle. Predicted to be active in extracellular matrix and extracellular space. Is expressed in several structures, including cochlea; jaw; renal cortex; skin; and telencephalon. Orthologous to human LGR6 (leucine rich repeat containing G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgr6 |
| Official Name | leucine-rich repeat-containing G protein-coupled receptor 6 [Source:MGI Symbol;Acc:MGI:2441805] |
| Ensembl ID | ENSMUSG00000042793 |
| Bio databases IDs | |
| Aliases | leucine-rich repeat-containing G protein-coupled receptor 6 |
| Synonyms | A530037C04RIK, D830026M09, GPCR, leucine-rich repeat-containing G protein-coupled receptor 6, RGD1560339, VTS20631 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lgr6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine rich repeat N-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- Leucine Rich repeats (2 copies)
- seven-transmembrane G protein-coupled receptor superfamily
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- breast carcinoma
- melanoma
- melanoma cancer
- gastric cancer
- restless legs syndrome
- colon carcinoma
- colon epithelial cancer
- estrogen receptor-negative breast cancer
role in cell
- signaling in
- migration
- proliferation
- tumorigenicity
- colony formation by
- self-renewal capacity
- downregulation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- vesicles
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lgr6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative chemotaxis
- G-protein coupled receptor signaling pathway
- positive regulation of canonical Wnt receptor signaling pathway
- axon guidance
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- vesicle
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- Roundabout binding
- transmembrane signaling receptor activity
- protein binding
- heparin binding
- protein-hormone receptor activity