Fcrls Gene Summary [Mouse]
Predicted to enable protein phosphatase binding activity; signaling adaptor activity; and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fcrls |
| Official Name | Fc receptor-like S, scavenger receptor [Source:MGI Symbol;Acc:MGI:1933397] |
| Ensembl ID | ENSMUSG00000015852 |
| Bio databases IDs | |
| Aliases | Fc receptor-like S, scavenger receptor |
| Synonyms | 2810439C17Rik, 9330158F12, CD307b, Fc receptor like 2, FCRH2, FcRH2sc, Fcrls, IFGP2, IFGP4, IgSR, IRTA4, MMAN-g, moFcRH2sc, Msr2, SPAP1, SPAP1A, SPAP1B, SPAP1C |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fcrls often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- C17orf99 Ig domain
- immunoglobulin domain
- protein phosphatase binding
- Immunoglobulin like
- protein binding activity, bridging
- Immunoglobulin I-set domain
- protein binding
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- streptozotocin induced type1 diabetes
- weight gain
- diabetic nephropathy
- laser induced choroidal neovascularization
regulates
- cholesterol
- LDL
role in cell
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fcrls gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- cell-cell signaling
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- external side of plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein phosphatase binding
- transmembrane signaling receptor activity
- protein binding
- signaling adaptor activity