Dmp1 Gene Summary [Mouse]
Enables extracellular matrix binding activity. Acts upstream of or within extracellular matrix organization; positive regulation of cell-substrate adhesion; and regulation of enamel mineralization. Located in cytoplasm; extracellular matrix; and nucleus. Is expressed in several structures, including alimentary system; bone; genitourinary system; limb; and nervous system. Used to study autosomal recessive hypophosphatemic rickets. Orthologous to human DMP1 (dentin matrix acidic phosphoprotein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmp1 |
| Official Name | dentin matrix protein 1 [Source:MGI Symbol;Acc:MGI:94910] |
| Ensembl ID | ENSMUSG00000029307 |
| Bio databases IDs | |
| Aliases | dentin matrix protein 1 |
| Synonyms | AG1, ARHP, ARHR, AV020965, dentin matrix acidic phosphoprotein 1, dentin matrix protein 1, DENTMAT, Dmp, PP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hsp70 protein binding
- extracellular matrix binding
- integrin binding
- nuclear localization sequence
- calcium ion binding
- Dentin matrix protein 1 (DMP1)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive hypophosphatemic rickets type 1
- osteomalacia
- primary hyperthyroidism
- hypophosphatemic rickets
- hypophosphatemia
- rickets
- sickle cell anemia
- autosomal recessive hypophosphatemic rickets
phenotypes
- abnormal kidney morphology
- enlarged kidney
- prolonged PR interval
- abnormal PR interval
- abnormal acellular cementum morphology
- abnormal alveolar process morphology
- abnormal bone marrow development
- abnormal bone mineralization involved in bone maturation
- abnormal bone remodeling
- abnormal cellular cementum morphology
- abnormal cementoblast morphology
- abnormal cementocyte canaliculus morphology
- abnormal cementocyte dendritic process morphology
- abnormal cementocyte lacuna morphology
- abnormal cementocyte lacunocanalicular system morphology
- abnormal cementum mineralization
- abnormal circulating protein level
- abnormal compact bone morphology
- abnormal dental pulp cavity morphology
- abnormal dentin development
- abnormal dentin mineralization
- abnormal dentin morphology
- abnormal kidney physiology
- abnormal long bone hypertrophic chondrocyte zone
- abnormal long bone metaphysis morphology
- abnormal osteocyte canaliculus morphology
- abnormal osteocyte lacuna morphology
- abnormal osteocyte lacunocanalicular system morphology
- abnormal osteocyte morphology
- abnormal periodontal ligament morphology
- abnormal periodontium morphology
- abnormal predentin morphology
- abnormal seminal vesicle morphology
- abnormal skeleton development
- abnormal tooth mineralization
- abnormal vascular development
- alveolar process atrophy
- arrested osteoblast differentiation
- decreased bone mineralization
- decreased cementoblast number
- decreased circulating calcium level
- decreased circulating phosphate level
- decreased heart weight
- decreased molar number
- decreased osteoclast cell number
- delayed bone ossification
- growth retardation of molars
- increased alkaline phosphatase activity
- increased bone trabecula number
- increased circulating parathyroid hormone level
- increased diameter of long bones
- increased osteoblast cell number
- increased osteoid volume
- increased susceptibility to bacterial infection
- misaligned teeth
- osteomalacia
- rachitic rosary
- reduced enamel thickness
- rickets
- short femur
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- migration
- differentiation
- cell cycle progression
- organization
- tubulogenesis in
- tubulogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- cytosol
- endoplasmic reticulum lumen
- extracellular matrix
- membrane processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of enamel mineralization
- ossification
- extracellular matrix organization
- positive regulation of cell-substrate adhesion
- biomineral tissue development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- nucleus
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- calcium ion binding
- integrin binding