Fnta Gene Summary [Mouse]
Enables Rab geranylgeranyltransferase activity; protein farnesyltransferase activity; and receptor tyrosine kinase binding activity. Involved in enzyme-linked receptor protein signaling pathway; positive regulation of Rac protein signal transduction; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within Rac protein signal transduction. Predicted to be part of CAAX-protein geranylgeranyltransferase complex; microtubule associated complex; and protein farnesyltransferase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including adipose tissue; alimentary system; brain; hemolymphoid system gland; and reproductive system. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fnta |
| Official Name | farnesyltransferase, CAAX box, alpha [Source:MGI Symbol;Acc:MGI:104683] |
| Ensembl ID | ENSMUSG00000015994 |
| Bio databases IDs | |
| Aliases | farnesyltransferase, CAAX box, alpha |
| Synonyms | farnesyltransferase, CAAX box, alpha, farnesyltransferase, CAAX box, subunit alpha, farnesyltransferase, CAAX box, subunit α, farnesyltransferase, CAAX box, α, FPTA, FTA, Ftase α, GGT alpha G/F, Ggtase 1-α, GGT α G/F, p21Ras alpha, p21Ras α, PFAS, PGGT1A, PTAR2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fnta often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- CAAX-protein geranylgeranyltransferase
- enzyme binding
- enzyme
- protein binding
- RAB-protein geranylgeranyltransferase
- enzyme activator activity
- cleavage site
- microtubule binding
- binding protein
- zinc ion binding
- receptor tyrosine kinase binding
- alpha-tubulin binding
- Protein prenyltransferase alpha subunit repeat
- protein geranylgeranyltransferase
- protein farnesyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- processing-deficient progeroid laminopathy
- hepatitis D
- non-small cell lung carcinoma
- Hutchinson-Gilford progeria syndrome
- chronic hepatitis D
- myelodysplastic syndrome
- ZMPSTE24 compound heterozygous mutation positive processing-deficient progeroid laminopathy
- chronic myelomonocytic leukemia
- infection by HIV-1
role in cell
- apoptosis
- proliferation
- growth
- cell death
- survival
- cell cycle progression
- activation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- neuromuscular junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fnta gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rac protein signal transduction
- skeletal muscle acetylcholine-gated channel clustering
- positive regulation of deacetylase activity
- protein farnesylation
- transforming growth factor beta receptor signaling pathway
- positive regulation of tubulin deacetylation
- protein geranylgeranylation
Cellular Component
Where in the cell the gene product is active
- protein farnesyltransferase complex
- CAAX-protein geranylgeranyltransferase complex
- cytoplasm
- cytosol
- plasma membrane
- microtubule associated complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein geranylgeranyltransferase activity
- alpha-tubulin binding
- protein farnesyltransferase activity
- Rab geranylgeranyltransferase activity
- CAAX-protein geranylgeranyltransferase activity
- receptor tyrosine kinase binding
- microtubule binding
- binding, bridging