Fntb Gene Summary [Mouse]
Enables geranylgeranyl diphosphate synthase activity. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of fibroblast proliferation; and wound healing. Predicted to be part of microtubule associated complex and protein farnesyltransferase complex. Human ortholog(s) of this gene implicated in anxiety disorder. Orthologous to several human genes including FNTB (farnesyltransferase, CAAX box, subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Fntb |
| Official Name | farnesyltransferase, CAAX box, beta [Source:MGI Symbol;Acc:MGI:1861305] |
| Ensembl ID | ENSMUSG00000033373 |
| Bio databases IDs | |
| Aliases | farnesyltransferase, CAAX box, beta |
| Synonyms | 2010013E13Rik, farnesyltransferase, CAAX box, beta, farnesyltransferase, CAAX box, subunit beta, farnesyltransferase, CAAX box, subunit β, farnesyltransferase, CAAX box, β, FPTB, FTase β, FT-beta, FT-β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fntb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prenyltransferase and squalene oxidase repeat
- ISOPREN_C2_like
- peptide binding
- zinc ion binding
- enzyme binding
- enzyme
- protein binding
- enzyme activator activity
- farnesyltranstransferase
- protein farnesyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial neoplasia
- epithelial cancer
- chronic hepatitis D
- major depression
- Hutchinson-Gilford progeria syndrome
- non-small cell lung carcinoma
- processing-deficient progeroid laminopathy
- ZMPSTE24 compound heterozygous mutation positive processing-deficient progeroid laminopathy
regulated by
- lonafarnib
- Influenza A virus (A/Bangkok/RX73(H3N2))
- EAhy926 cells
- cortisone acetate
- tipifarnib
- TCF7L2
- FTI-277
- phytohemagglutinin
role in cell
- growth
- proliferation
- cell cycle progression
- farnesylation in
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fntb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- protein farnesylation
Cellular Component
Where in the cell the gene product is active
- protein farnesyltransferase complex
- cytosol
- microtubule associated complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- protein farnesyltransferase activity