Psmd11 Gene Summary [Mouse]
Predicted to enable structural molecule activity. Predicted to be involved in proteasome assembly; stem cell differentiation; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in central nervous system; heart; liver; neural retina; and skeletal muscle. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Psmd11 |
| Official Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [Source:MGI Symbol;Acc:MGI:1916327] |
| Ensembl ID | ENSMUSG00000017428 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
| Synonyms | 1700089D09RIK, 1810019E17Rik, 2610024G20Rik, 2810055C24Rik, P44.5, proteasome 26S subunit, non-ATPase 11, proteasome (prosome, macropain) 26S subunit, non-ATPase, 11, Rpn6, S9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmd11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- 26S proteasome regulatory subunit RPN6 N-terminal domain
- protein binding
- 26S proteasome subunit RPN6 C-terminal helix domain
Pathways
Biological processes and signaling networks where the Psmd11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- growth failure
regulates
- 26S proteasome
- proteasome
role in cell
- cell death
- differentiation
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmd11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- stem cell differentiation
- proteasome assembly
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- cytosol
- secretory granule lumen
- proteasome complex
- proteasome accessory complex
- proteasome regulatory particle, lid subcomplex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity