Rfc3 Gene Summary [Mouse]
Predicted to enable ATP-dependent activity, acting on DNA. Predicted to contribute to DNA binding activity; DNA clamp loader activity; and single-stranded DNA helicase activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Is expressed in central nervous system; liver; retina nuclear layer; skeletal muscle; and submandibular gland primordium. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rfc3 |
| Official Name | replication factor C (activator 1) 3 [Source:MGI Symbol;Acc:MGI:1916513] |
| Ensembl ID | ENSMUSG00000033970 |
| Bio databases IDs | |
| Aliases | replication factor C (activator 1) 3 |
| Synonyms | 2810416I22Rik, p38, RECC3, replication factor C (activator 1) 3, replication factor C subunit 3, RFC, RFC38 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rfc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- LXXLL motif
- DNA polymerase III, delta subunit
- ATP-binding domain
- Rad17 P-loop domain
- enzyme
- protein binding
- DNA dependent ATPase
- DNA binding
- AAA domain
- helical lid domain of clamp loader-like AAA+ proteins
- DNA clamp loader
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Rfc3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- small cell lung cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
- epithelial uterine cancer
- cervical cancer
role in cell
- production in
- proliferation
- binding in
- processing in
- homologous recombination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rfc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA strand elongation involved in DNA replication
- DNA replication
- DNA duplex unwinding
- DNA-dependent DNA replication
- response to organophosphorus
- positive regulation of DNA-directed DNA polymerase activity
- DNA synthesis involved in DNA repair
Cellular Component
Where in the cell the gene product is active
- Ctf18 RFC-like complex
- nucleus
- DNA replication factor C complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- DNA binding
- DNA clamp loader activity
- DNA-dependent ATPase activity
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity