Dock1 Gene Summary [Mouse]
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Acts upstream of or within cell migration and hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in several cellular components, including glutamatergic synapse; plasma membrane; and postsynapse. Is expressed in several structures, including dermomyotome; genitourinary system; heart; hemolymphoid system gland; and midgut vascular element. Used to study DiGeorge syndrome and tetralogy of Fallot. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Dock1 |
| Official Name | dedicator of cytokinesis 1 [Source:MGI Symbol;Acc:MGI:2429765] |
| Ensembl ID | ENSMUSG00000058325 |
| Bio databases IDs | |
| Aliases | dedicator of cytokinesis 1 |
| Synonyms | 9130006G06Rik, AI854900, b2b3190Clo, ced5, D630004B07Rik, dedicator of cyto-kinesis 1, DOCK180, LOC100909609, LOC679295, RGD1566072 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dock1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DHR-2, Lobe B
- C2 domain in Dock180 and Zizimin proteins
- DOCK homology region 1
- DHR-2, Lobe A
- GTPase activator
- DOCK N-terminus
- protein binding
- CDM-zizimin homology domain
- proline rich domain
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
- crk/CRKL binding domain
- Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
- basic amino acid motif
- DOCK homology region 2
- guanyl-nucleotide exchange factor
- C2 domain
- DHR-2, Lobe C
Pathways
Biological processes and signaling networks where the Dock1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioma formation
- edema
- schizophrenia
- glioblastoma
- glioblastoma cancer
- hereditary disorder
- idiopathic scoliosis
- prostate cancer
- Hutchinson-Gilford progeria syndrome
role in cell
- activation in
- expression in
- invasion by
- apoptosis
- Gap 0-Gap 1 phase
- proliferation
- migration
- cell death
- formation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- focal adhesions
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nuclear speckles
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dock1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- integrin-mediated signaling pathway
- phagocytosis, engulfment
- signal transduction
- small GTPase mediated signal transduction
- apoptotic process
- myoblast fusion
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of epithelial cell migration
- cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear speck
- cytosol
- guanyl-nucleotide exchange factor complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding
- SH3 domain binding