Serinc3 Gene Summary [Mouse]
Predicted to enable phospholipid scramblase activity. Acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Located in Golgi apparatus and plasma membrane. Is expressed in several structures, including adrenal medulla; craniocervical region bone; ganglia; liver lobe; and thymus primordium. Orthologous to human SERINC3 (serine incorporator 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serinc3 |
| Official Name | serine incorporator 3 [Source:MGI Symbol;Acc:MGI:1349457] |
| Ensembl ID | ENSMUSG00000017707 |
| Bio databases IDs | |
| Aliases | serine incorporator 3 |
| Synonyms | AIGP1, DIFF33, MGC94574, SBBI99, serine incorporator 3, TDE, TDE1, TMS-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serinc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid scramblase
- transmembrane domain
- Serine incorporator (Serinc)
- protein binding
- serine transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- rheumatoid arthritis
- lymphomagenesis
- B cell cancer
- B-cell neoplasia
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
role in cell
- cell death
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Serinc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- L-serine biosynthetic process
- defense response to virus
- L-serine transport
- detection of virus
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-serine transmembrane transporter activity