Med20 Gene Summary [Mouse]
Predicted to enable transcription coactivator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within skeletal muscle cell differentiation. Part of mediator complex. Is expressed in several structures, including early conceptus; eye; limb mesenchyme; oocyte; and tongue. Orthologous to human MED20 (mediator complex subunit 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med20 |
| Official Name | mediator complex subunit 20 [Source:MGI Symbol;Acc:MGI:1929648] |
| Ensembl ID | ENSMUSG00000092558 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 20 |
| Synonyms | 1110011O05Rik, 2410115I17Rik, LOC100360472, LOC501098, mediator complex subunit 20, P28a, PRO0213, SRB2, TRFP, Usp49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ubiquitin protein ligase activity
- protein binding
- TATA-binding related factor (TRF) of subunit 20 of Mediator complex
Pathways
Biological processes and signaling networks where the Med20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- productive infection by HIV-1
regulated by
- beta-estradiol
- E. coli B5 lipopolysaccharide
- 2-amino-5-phosphonovaleric acid
- Lmp2a
- trovafloxacin
- TBX2
role in cell
- cell death
- production in
- synthesis in
- differentiation
- transcription in
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- skeletal muscle cell differentiation
- transcription, DNA-dependent
- positive regulation of transcription initiation from RNA polymerase II promoter
- transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- mediator complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- DNA-directed RNA polymerase activity
- transcription coactivator activity