Myh11 Gene Summary [Mouse]
Enables cytoskeletal motor activity. Acts upstream of or within smooth muscle contraction. Located in brush border; smooth muscle contractile fiber; and stress fiber. Part of muscle myosin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and vascular system. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome; patent ductus arteriosus; and thoracic aortic aneurysm. Orthologous to human MYH11 (myosin heavy chain 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myh11 |
| Official Name | myosin, heavy polypeptide 11, smooth muscle [Source:MGI Symbol;Acc:MGI:102643] |
| Ensembl ID | ENSMUSG00000018830 |
| Bio databases IDs | |
| Aliases | myosin, heavy polypeptide 11, smooth muscle |
| Synonyms | AAT4, circMYH11, circRNA-MYH11, FAA4, LOC100506151, MYOSIN HEAVY CHAIN 11, myosin heavy chain, smooth muscle, myosin, heavy polypeptide 11, smooth muscle, SM1, SM2, SM2-MHC, SMHC, SM MHC, SMMS-1, SMOOTH MUSCLE MYOSIN, VSCM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myh11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- regulatory domain
- Synaptonemal complex protein 1 (SCP-1)
- Autophagy protein ATG17-like domain
- Myosin N-terminal SH3-like domain
- helix-rich Mycoplasma protein
- coiled-coil domain
- Tektin family
- motor domain
- head domain
- chromosome segregation protein SMC, common bacterial type
- tail domain
- rod domain
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Crescentin protein
- Rabaptin-like protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- Myosin and Kinesin motor domain
- Hyaluronan mediated motility receptor N-terminal
- Domain of unknown function (DUF4618)
- ALIX V-shaped domain binding to HIV
- rad50
- Myosin tail
- SWI5-dependent HO expression protein 3
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Protein of unknown function (DUF3584)
- Myosin head (motor domain)
- Alpha helical coiled-coil rod protein (HCR)
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- structural constituent of muscle
- Growth-arrest specific micro-tubule binding
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- motor protein
- Apolipoprotein A1/A4/E domain
- Myosin
Pathways
Biological processes and signaling networks where the Myh11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- Alzheimer disease
- insulin-dependent diabetes mellitus
- lymphomagenesis
- asthma
- visceral myopathy type 2
- uterine serous papillary cancer
- megacystis-microcolon-intestinal hypoperistalsis syndrome type 2
- coronary artery disease
- Marfan syndrome
role in cell
- expression in
- proliferation
- apoptosis
- migration
- degradation in
- survival
- differentiation
- abnormal morphology
- development
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- cytosol
- myofibrils
- actin stress fibers
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myh11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- elastic fiber assembly
- actomyosin structure organization
- smooth muscle contraction
- cardiac muscle cell development
- skeletal muscle myosin thick filament assembly
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- muscle myosin complex
- cytoplasm
- melanosome
- myosin II complex
- myosin filament
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- calmodulin binding
- protein binding
- structural constituent of muscle
- microfilament motor activity