Pde4d Gene Summary [Mouse]
Enables several functions, including ATPase binding activity; calcium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including cAMP/PKA signal transduction; regulation of calcium ion transmembrane transport; and regulation of heart contraction. Acts upstream of or within several processes, including cellular response to follicle-stimulating hormone stimulus; neutrophil chemotaxis; and ovulation from ovarian follicle. Located in centrosome. Part of potassium channel complex and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pde4d |
| Official Name | phosphodiesterase 4D, cAMP specific [Source:MGI Symbol;Acc:MGI:99555] |
| Ensembl ID | ENSMUSG00000021699 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 4D, cAMP specific |
| Synonyms | 3,5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE, 9630011N22RIK, ACRDYS2, AI452195, DPDE3, HSPDE4D, LOC100040968, LOC100044853, LOC100504580, LOC103695092, LOC107986349, PDE3/IVd, PDE43, PDE4DN2, phosphodiesterase 4D, phosphodiesterase 4D, cAMP specific, ROLIPRAM-SENSITIVE 3,5'-CYCLIC AMP PHOSPHODIESTERASE, STRK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pde4d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'5'-cyclic nucleotide phosphodiesterase
- regulatory domain
- G-protein-coupled receptor binding
- upstream conserved regions 2
- inhibitory domain
- enzyme
- zDHHC ankyrin repeat binding domain
- 3',5'-cyclic-nucleotide phosphodiesterase
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3',5'-cAMP binding
- upstream conserved region
- ion channel binding
- HDc
- Phosphodiesterase 4 upstream conserved regions (UCR)
- upstream conserved regions 1
- autoinhibitory protein domain
- receptor regulator
- catalytic domain
- cAMP-specific phosphodiesterase
- alpha helix
- enzyme binding
- linker domain
- protein binding
- calcium channel regulator
- cyclic-nucleotide phosphodiesterase
- ATPase binding
- binding protein
Pathways
Biological processes and signaling networks where the Pde4d gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HIV infection
- endometriosis
- cancer
- alopecia areata
- lung carcinoma
- colorectal cancer
- pain
- psoriasis
- seborrheic dermatitis
regulated by
- isobutylmethylxanthine
- forskolin
- LH
- dexamethasone
- CG
- FSH
- indomethacin
- 8-bromo-cAMP
- bucladesine
- ITGA5
role in cell
- apoptosis
- growth
- activation in
- proliferation
- expression in
- migration
- differentiation
- quantity
- recruitment
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytocentrum fractions
- soluble fraction
- cytoskeleton
- cilia
- Golgi-centrosome region
- cellular membrane
- manchette
- actin cytoskeleton
- Plasma Membrane
- centrosome
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear envelope
- myofibrils
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pde4d gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
- regulation of cardiac muscle cell contraction
- cAMP catabolic process
- establishment of endothelial barrier
- negative regulation of heart contraction
- regulation of heart rate
- positive regulation of interferon-gamma production
- adrenergic receptor signaling pathway
- negative regulation of peptidyl-serine phosphorylation
- cAMP-mediated signaling
- T cell receptor signaling pathway
- positive regulation of interleukin-5 production
- positive regulation of interleukin-2 production
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- perinuclear region of cytoplasm
- calcium channel complex
- voltage-gated calcium channel complex
- cytosol
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- 3',5'-cyclic-GMP phosphodiesterase activity
- calcium channel regulator activity
- ion channel binding
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity
- scaffold protein binding
- protein binding
- metal ion binding
- cAMP binding
- receptor regulator activity
- ATPase binding
- enzyme binding
- beta-2 adrenergic receptor binding