Rcn3 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Involved in several processes, including ERAD pathway; phospholipid homeostasis; and surfactant homeostasis. Located in endoplasmic reticulum. Is expressed in several structures, including aorta; brain; genitourinary system; gut gland; and trachea. Orthologous to human RCN3 (reticulocalbin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rcn3 |
| Official Name | reticulocalbin 3, EF-hand calcium binding domain [Source:MGI Symbol;Acc:MGI:1277122] |
| Ensembl ID | ENSMUSG00000019539 |
| Bio databases IDs | |
| Aliases | reticulocalbin 3, EF-hand calcium binding domain |
| Synonyms | 6030455P07Rik, D530026G20RIK, D7ERTD671E, Rem1, reticulocalbin 3, reticulocalbin 3, EF-hand calcium binding domain, RLP49 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rcn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- calcium ion binding
- EFh
- EF-hand, calcium binding motif, found in CREC-EF hand family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- dyspnea
- respiratory failure
- colorectal cancer
- organismal death
- cyanosis
- glioblastoma
- glioblastoma cancer
- atelectasis
- hypertrophic scarring
role in cell
- expression in
- proliferation
- abnormal morphology
- self-renewal
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rcn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein kinase B signaling cascade
- protein transport
- positive regulation of peptidase activity
- lung epithelium development
- collagen biosynthetic process
- protein secretion
- phospholipid homeostasis
- surfactant homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- intracellular membrane-bounded organelle
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding