Lyst Gene Summary [Mouse]
Acts upstream of or within several processes, including defense response to other organism; phospholipid homeostasis; and vesicle organization. Located in cytosol. Is expressed in axial skeleton. Used to study Chediak-Higashi syndrome; exfoliation syndrome; and platelet storage pool deficiency. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lyst |
| Official Name | lysosomal trafficking regulator [Source:MGI Symbol;Acc:MGI:107448] |
| Ensembl ID | ENSMUSG00000019726 |
| Bio databases IDs | |
| Aliases | lysosomal trafficking regulator |
| Synonyms | Beige, bg, CHS, CHS1, D13Sfk13, Lysosomal trafficking regulator, LYST-IT1, Mauve |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lyst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Pleckstrin homology-like domain
- transporter
- Beach
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Chédiak-Steinbrinck-Higashi syndrome
- hereditary cancer-predisposing syndrome
- hereditary disorder
- adult type Chediak-Higashi syndrome
- epithelial neoplasia
- systemic lupus erythematosus
- multiple sclerosis
- hereditary spastic ataxia
- epithelial cancer
phenotypes
- abnormal coat/hair pigmentation
- abnormal iris morphology
- abnormal retina morphology
- decreased neutrophil cell number
- developmental dysplasia
- increased fasting circulating glucose level
- increased lymphocyte cell number
- increased mean corpuscular volume
- abnormal NK cell physiology
- abnormal anterior uvea morphology
- abnormal choroid pigmentation
- abnormal ciliary body pigmentation
- abnormal dermal layer morphology
- abnormal dermal mast cell morphology
- abnormal eosinophil morphology
- abnormal eye anterior chamber morphology
- abnormal eye pigmentation
- abnormal foot pigmentation
- abnormal gait
- abnormal granulocyte morphology
- abnormal hair follicle melanocyte morphology
- abnormal hair shaft melanin granule shape
- abnormal hippocampal mossy fiber morphology
- abnormal hippocampus pyramidal cell layer
- abnormal iridocorneal angle
- abnormal iris pigment epithelium
- abnormal iris pigmentation
- abnormal iris stroma morphology
- abnormal lung development
- abnormal lymphocyte morphology
- abnormal lysosome morphology
- abnormal lysosome physiology
- abnormal melanocyte morphology
- abnormal melanosome morphology
- abnormal neutrophil morphology
- abnormal retinal layer morphology
- abnormal retinal pigment epithelium morphology
- abnormal retinal pigmentation
- abnormal skin morphology
- abnormal skin pigmentation
- abnormal type II pneumocyte morphology
- abnormal urine enzyme level
- abnormal vestibuloocular reflex
- absent NK T cells
- absent hair follicle melanin granules
- accumulation of giant lysosomes in kidney/renal tubule cells
- altered metastatic potential
- altered susceptibility to infection
- altered tumor susceptibility
- alveolitis
- atelectasis
- decreased Purkinje cell number
- decreased cytotoxic T cell cytolysis
- decreased ear pigmentation
- decreased eye pigmentation
- decreased lysosomal enzyme secretion
- decreased macrophage cell number
- decreased metastatic potential
- decreased platelet ADP level
- decreased platelet ATP level
- decreased platelet serotonin level
- decreased susceptibility to fungal infection
- decreased tail pigmentation
- delayed hair regrowth
- diluted coat color
- ectopic Bergmann glia cells
- ectopic Purkinje cell
- ectopic cerebellar granule cells
- ectopic hippocampus pyramidal cells
- emphysema
- enhanced behavioral response to xenobiotic
- enlarged alveolar lamellar bodies
- enlarged hair follicle melanin granules
- enlarged melanosome
- hypopigmentation
- impaired balance
- impaired lung alveolus development
- impaired macrophage phagocytosis
- impaired natural killer cell mediated cytotoxicity
- impaired swimming
- increased bleeding time
- increased incidence of induced tumors
- increased kidney weight
- increased susceptibility to Herpesvirales infection
- increased susceptibility to bacterial infection
- increased susceptibility to parasitic infection
- lysosomal protein accumulation
- overexpanded pulmonary alveoli
- paraparesis
- premature hair loss
- pulmonary fibrosis
- tremors
role in cell
- phosphorylation in
- activation in
- quantity
- disruption
- activation
- organization
- morphology
- chemotaxis by
- recruitment in
- trafficking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- microtubules
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lyst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mast cell secretory granule organization
- protein transport
- protein localization
- natural killer cell mediated cytotoxicity
- defense response to bacterium
- defense response to protozoan
- melanosome organization
- pigmentation
- phagocytosis
- endosome to lysosome transport via multivesicular body sorting pathway
- defense response to virus
- leukocyte chemotaxis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding