Lyst Gene Summary [Mouse]
Acts upstream of or within several processes, including defense response to other organism; phospholipid homeostasis; and vesicle organization. Located in cytosol. Is expressed in axial skeleton. Used to study Chediak-Higashi syndrome; exfoliation syndrome; and platelet storage pool deficiency. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lyst |
| Official Name | lysosomal trafficking regulator [Source:MGI Symbol;Acc:MGI:107448] |
| Ensembl ID | ENSMUSG00000019726 |
| Bio databases IDs | |
| Aliases | lysosomal trafficking regulator |
| Synonyms | Beige, bg, CHS, CHS1, D13Sfk13, Lysosomal trafficking regulator, LYST-IT1, Mauve |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lyst often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Pleckstrin homology-like domain
- transporter
- Beach
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Chédiak-Steinbrinck-Higashi syndrome
- hereditary cancer-predisposing syndrome
- hereditary disorder
- adult type Chediak-Higashi syndrome
- epithelial neoplasia
- systemic lupus erythematosus
- multiple sclerosis
- hereditary spastic ataxia
- epithelial cancer
role in cell
- phosphorylation in
- activation in
- quantity
- disruption
- activation
- organization
- morphology
- chemotaxis by
- recruitment in
- trafficking in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- microtubules
- cytosol
- cytoplasmic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lyst gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mast cell secretory granule organization
- protein transport
- protein localization
- natural killer cell mediated cytotoxicity
- defense response to bacterium
- defense response to protozoan
- melanosome organization
- pigmentation
- phagocytosis
- endosome to lysosome transport via multivesicular body sorting pathway
- defense response to virus
- leukocyte chemotaxis
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding