Efs Gene Summary [Mouse]
Enables SH3 domain binding activity. Predicted to be involved in cell migration and cell surface receptor protein tyrosine kinase signaling pathway. Predicted to be active in cytoplasm and focal adhesion. Predicted to colocalize with plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Used to study Crohn's disease. Orthologous to human EFS (embryonal Fyn-associated substrate). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Efs |
| Official Name | embryonal Fyn-associated substrate [Source:MGI Symbol;Acc:MGI:105311] |
| Ensembl ID | ENSMUSG00000022203 |
| Bio databases IDs | |
| Aliases | embryonal Fyn-associated substrate |
| Synonyms | CAS3, CASS3, EFS1, EFS2, embryonal Fyn-associated substrate, HEFS, SIN, Sin2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Efs often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAT-like_CAS_C
- protein domain specific binding
- protein binding
- SH3-domain binding
- Src Homology 3 domain superfamily
- Crk-Associated Substrate C-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
role in cell
- proliferation
- cellular infiltration by
- function
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Efs gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane receptor protein tyrosine kinase signaling pathway
- cell adhesion
- cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- SH3 domain binding